Sweeping gun control overhaul efforts hit a major roadblock on Capitol Hill today. The Senate rejected a bipartisan plan to expand federal background checks to include gun shows and online purchases. The amendment was part of a package of Obama-backed bills prompted by the Newtown, CT, school shooting.

The legislation was the result of a bipartisan compromise by Republican Pat Toomey and Democrat Joe Manchin. The defeat, while anticipated, was a crushing blow to supporters of stricter gun control laws. Vice President Joe Biden said just before the vote that tighter gun control measures will eventually pass, suggesting the White House wouldn’t abandon its push even though the vote appeared headed toward failure.

The Senate will consider nearly a dozen more amendments in the coming days, including a ban on certain assault rifles.

The Associated Press contributed to this report